Dominant Negative Effectors of Heparin Affin Regulatory Peptide (HARP) Angiogenic and Transforming Activities
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منابع مشابه
P 363 Heparin affin regulatory peptide (HARP) in human ocular tissues
T1TI.E SURFACE STRXXUTG (IF RABBIT VIlF'EO-Xb'l'lNAL JUNCTIDN AFTER ENZiMATTC !IEPARAT'TON OF INNER LIMITIN:: MBMBRaNE. CILVETI A. T.APEIRk VI. and GARCln CANFOS J!-l ueparcment of Ophthalmo'iocgy Urlivrrsicy of Malaga. Pu+pooc.1n order to inves?:qato the etrxct~rr :,f the inner Iuniting nembranil (TLMJ and r hC vi:reoretlnal 8trscttire. I.hn TLM was Bei>ara;ad +ron the retina irl rabbrt rlpcci...
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BACKGROUND Heparin affin regulatory peptide (HARP) is an 18-kDa secreted protein that has been implicated in tumor growth and angiogenesis, although the mechanisms involved remain largely unknown. In the present work, the effect of human recombinant HARP on the expression of the vascular endothelial growth factor (VEGF) receptors KDR, Flt-1 and neuropilin-1 was studied in cultured human umbilic...
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We have previously identified and characterized a heparin-binding cell surface protein (heparin/heparan sulfate-interacting protein, or HIP) present on epithelial and endothelial cells. A synthetic peptide mimicking a heparin-binding domain of HIP is now shown to bind a small subset of heparin molecules with high affinity and, therefore, presumably recognizes a specific structural motif in the ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m202747200